|  Methylfolate for Depression

Methylfolate for Depression

depressionHere is a mainstream study advocating the use of a special form of the B vitamin, folic acid. How does it work? To make neurotransmitters, we need methyl groups. If we don’t make methyl groups due to a genetic variation (could be as high as 30% of the population), we have trouble making neurotransmitters, and can become depressed. The solution? take methylfolate! It’s included in my Brain Recovery AM/PM packets and in Better Balance 2-a-Day multivitamins. Take that along with the requisite amino acids (also contained in Brain Recovery packets) and then you likely won’t even need an antidepressant.

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5 Responses to Methylfolate for Depression

  1. LeeAnn Reply

    April 8, 2013 at 8:05 pm

    Dr, do you offer anything that balances bipolar mania?

  2. Rebecca Reply

    March 21, 2013 at 5:47 am

    Thank you!! This is completely the answer I wanted! I think this sounds great and I need it. I’m so happy I found your site. Wonderful!

  3. Rebecca Reply

    March 17, 2013 at 8:57 pm

    I am taking both Cymbalta and Tegretol. Could I take methylfolate or yet another supplement? I want to feel good — happy, motivated, and energetic. Thank you so much!

    • Hyla Cass, MD Reply

      March 19, 2013 at 12:40 am

      The short answer is “yes you can.” In fact, methylfolate is often given along with an antidepressant to boost it’s activity, especially in cases of “treatment resistance;” i.e. the medication isn’t working well enough.

      So what is methylfolate? Methylfolate is a special form of the B vitamin that is more usable by the body than it’s precursor, folic acid.

      How does it work? To make neurotransmitters, we need methyl groups for a process called methylation. If due to a genetic variation (could be as high as 30% of the population), we don’t make methyl groups, we have trouble making neurotransmitters, and can become depressed.

      The solution? Take methylfolate! it should also be taken along with other B vitamins to be complete, especially B6 and B12. Take these vitamins along with the requisite amino acids (also contained in Brain Recovery packets), especially if you want to get off the antidepressant. The vitamins are included in both my Brain Recovery AM/PM packets and in Better Balance 2-A-Day multivitamins.

      If someone is already on an antidepressant, as you are, you can still take the Brain Recovery but take the PM packet at least 2 hrs away from the medication, which is a selective serotonin reuptake inhibitor, to avoid possible (and rare) serotonin syndrome). Why? The PM packet contains 5-HTP, an amino acid that helps to make serotonin. Otherwise, just add in Better Balance 2-A-Day multivitamins which has no 5 HTP. And check with your doctor.

      • Julio Reply

        April 6, 2013 at 12:04 am

        Hi Dr. Cass. I found your website recently. I’m very impressed with the information you provide. My conditions are major depressive disorder, anxiety disorders (OCD and Panic Disorder), and migraines. Right now, I’m taking Pristiq 50 mg, Klonopin (2 mg maximum recommended dose), and Elavil 50 mg. All the meds have helped me. It’s a fact. But I’ve been told that I need the meds for the rest of my life in order to have quality of life. Is hard for a patient to accept that cold reality. Also, I’ve gained 60 pounds in the process I’m 31 years old, and I used to lift weights and play basketball. Cardio is something I still do like 2 times a week.

        Nonetheless, a natural approach is what I’m looking for and want to give it a shot. I want my health back. I’ve read a lot about natural remedies like 5-HTP, Sam-e, Rhodiola Rosea, St. John’s Wort. Also, Relora and Suntheanine attract my attention since anxiety is my worst problem. I tried Super Cortisol Support once and the label states that it’s recommended by you. I noticed positive results. Methylfolate, the B-vitamin, came to my attention on this website.

        I understand that you cannot provide medical advice over the Internet, but you can recommend the books that I need to read (your own books). Also, you have your own line of supplements. You can help me with that. I guess I’ll have to work with my psychiatrist to quit the meds slowly and safely. Also a second (third) opinion is not a bad idea.

        Your medical recommendations are unorthodox coming from a psychiatrist. And to tell you the truth, I like that. It gives me hope. This month I’m planning to see an ND and a traditional Chinese medicine doctor. Can you at least give me general recommendations?? I’m asking for your help since it’s very hard (trust me on this one) to find a psychiatrist with your point of view. Whatever you can do to help will be truly appreciated. By the way, sorry for the long message. I tried to send you an email, but it cannot be done right now (Error 404).

        Cordially,
        Julio :-)

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