I’m in San Diego for the A4M (anti-aging medicine) Hormone Module, where I just spoke to an enthusiastic group of doctors about “Women, Mood and Hormones”, and how women’s hormones interact with and influence our neurotranmitters and mood. So instead of an antidepressant, consider neurotransmitter precursors (amino acids, vitamins, minerals) and bio-identical hormones. This was courtesy of RLC, manufacturer’s of Nature-throid, the natural dessicated thryoid product that I prescribe in my practice. I am attending this 2 day seminar at the lovely Marriott Marquis on the bay, and learning things like the best tests for hormones (urine vs blood vs saliva), best delivery systems (oral, transdermal, etc) and best timing for either prescribing ot taking them. There is a lot to know here! I’d encourage my colleagues to look at this course and my readers, to seek out docs who are trained in this topic.
Now for the brain. This article is from my distributor and web host, Jim English, who is also the manufacturer of Tango Advanced Nutrition Products, a superior very effective line of supplement formulas.
Alzheimer’s Disease (AD) is a progressive degenerative disease that most commonly appears after the age of 50. Currently, Alzheimer’s afflicts approximately 40% of all individuals over the age of 85, for a total of 4 million people in the U.S. alone. When symptoms occur before the age of 65 the disease is designated Presenile Dementia of the Alzheimer’s Type (PDAT). When symptoms occur after age 65 the syndrome is referred to as Senile Dementia of the Alzheimer’s Type (SDAT). Symptoms include a gradual yet inexorable loss of memory, mental performance, communication skills, abstract thinking and personality. Ultimately, Alzheimer’s ends in the death of the patient, with a mean life expectancy of 8 years.
As well as being a profound personal tragedy for afflicted individuals and their loved ones, the financial costs of caring for victims of the disease exceed $80 billion per year. The current trend towards longer life expectancy, combined with the increased incidence of senile dementia with age, means that cases of Alzheimer’s increase alarmingly as the median age of the population grows, underscoring the urgency for finding an effective treatment for this disorder.
Huperzine-A, a natural supplement derived from an ancient traditional Chinese herbal medicine, offers hope for those seeking to support and protect memory and healthy brain function.
Cholinergic Dysfunction in Alzheimer’s
Alzheimer’s is characterized by the destruction of nerve cells in several key areas of the brain devoted to mental functions. This results in tangles of nerve fibers and plaque formation of an abnormal, insoluble protein called amyloid. While there is a general reduction in the concentration of all neurotransmitting substances, a marked clinical feature of the disease is a dramatic decrease in the neurotransmitter acetylcholine.
Acetylcholine is a vital neurotransmitter with a fundamental role in memory. It is also necessary for proper intracellular communication between nerve cells. Research has shown that levels of acetylcholine are deficient in the brains of patients with Alzheimer’s disease.
Biopsy and postmortem studies have shown that there is a substantial loss of presynaptic cholinergic neurons in brains of patients with Alzheimer’s. What little acetylcholine that is still produced in the patient’s brain is quickly broken down by the brain enzyme, acetylcholinesterase (AchE), leading to a shortage of the neurotransmitter and contributing to the patient’s loss of memory and other cognitive functions.
Prescription Alzheimer’s Drugs
Two drugs are currently approved for use in the U.S. to treat Alzheimer’s—Tacrine™ and Donepezil hydrochloride (Aricept™). Both drugs are moderately effective cholinesterase inhibitors, that work by interfering with the actions of AChE. Since acetylcholine is normally degraded and recycled by acetylcholinesterase, this approach counteracts any further reduction of already low levels of acetylcholine.
By inhibiting the actions of AChE it is hoped that the small amounts of acetylcholine still being produced will persist longer within the synaptic cleft and lead to improvements in memory and cognitive abilities.
While both drugs are effective cholinesterase inhibitors, they suffer from a number of drawbacks. First, they are available only by prescription; second, they are expensive, costing between $100 – $240 per month; and third, both drugs can cause debilitating side effects including liver toxicity (Tacrine), and nausea and diarrhea (Donepezil).
Huperzine A: A Safe Alternative
Huperzine A is a natural compound derived from the ancient Chinese remedy, Qian Ceng Ta, a traditional herbal medicine prepared from Huperzia serrata, a clubmoss that grows on the ground in damp forests and rock crevices. Brewed as an herbal tea, Qian Ceng Ta has been used for centuries to treat fever, inflammation, and irregular menstruation, and has been used as a diuretic.
In the late 1980’s, researchers in China discovered that a purified alkaloid extracted from Huperzia, Huperzine A, was a potent, reversible inhibitor of acetylcholinesterase (AChE). Huperzine A readily crosses the blood-brain barrier to prevent acetylcholinesterase from destroying acetylcholine.
Molecular Monkey Wrench
A study at the Weizmann Institute in Israel uncovered how Huperzine A (Hup-A) works to block acetylcholinesterase. Scientists had previously learned that AchE inhibitors such as tacrine and donepezil worked by sliding into the AChE molecule to “jam up” its molecular machinery and impair its ability to degrade acetylcholine.
By imaging a 3-dimensional structure of the AChE molecule, the researchers were able to peer into the complex folded protein structure to discover a deep chasm, called the active-site gorge. The scientists determined that the active-site gorge acts as a guide to funnel acetylcholine into the interior of the enzyme where it is cut apart prior to recycling.
This study revealed that Huperzine A has a strong specificity for AChE, and is exceptionally well suited to its new role, fitting into the active sites of acetylcholinesterase much like a key slipping into a lock. “Hup-A appears to bind more tightly and specifically to acetylcholinesterase than the other AChE inhibitors,” crystallographer Prof. Joel Sussman, one of the authors of the study said.
“It is as if this natural substance were ingeniously designed to fit into the exact spot in AChE where it will do the most good.”
Double-blind, placebo-controlled clinical trials have demonstrated that adults dealing with a variety of memory issues gain significant benefit, both in terms of memory and life quality. In one placebo-controlled, double-blind study, subjects were given 200 mcg/day Hup-A or placebo for 8 weeks. Statistically significant improvement was achieved in 58% of the treated group with respect to cognitive function and their ability to retrieve past memories.
In a second study, researchers concluded that Hup-A had a high rate of absorption and distribution in the body, and was without adverse side effects.
Another study focused on the efficacy of Hup-A on memory, cognition, and behavior. This multicenter, double-blind, placebo controlled study found that about 58% (29/50) of adults receiving Hup A showed improvements in their memory, cognition, and behavioral functions. No severe side effects were found. All patients were evaluated with Wechsler memory scale, Hasegawa dementia scale, mini-mental state examination scale and activity of daily living scale. Their conclusion was that Hup-A is a promising agent for supporting memory and cognitive function.
In the U.S., a paper by noted neurologist, Alan A. Mazurek, M.D., reported on the results of an office-based trial studying the safety and efficacy of Hup-A. Mazurek evaluated the safety and efficacy of Hup-A in an open-label trial involving 29 patients with mild to moderate memory issues.
Twenty-two patients (75.9%) completed the three month study. No gastrointestinal side effects, nausea, diarrhea, cardiac effects or headache were reported. Status Examinations’ (SMMSE) improvement of one point or greater was seen at one, two and three months. Mazurek reported that improvements appeared to be dose related, with those on the higher dosages exhibiting the greatest improvement. Wrote Mazurek, “Huperzine A appears to be safe, well tolerated, and effective in the symptomatic treatment.”
In addition to its activity as an AChE inhibitor, ongoing research suggests that Hup-A has a wider role to play in supporting neuroprotective functions. Researchers recently discovered that Hup-A inhibits glutamate-induced cytotoxicity, protecting neonatal hippocampal and cerebellar neuronal cells in culture from death caused by the amino acid glutamate. In addition to protecting from glutamate-induced cytotoxicity, researchers were also surprised to learn that Huperzine A promotes new dendrite outgrowth of neuronal cultures.
Huperzine A has a wide margin of safety. Toxicology studies show Huperzine A to be non-toxic even when administered at 50-100 times the human therapeutic dose! The extract is active for 6 hours at a dose of 2 µg/kg with no remarkable side effects.
Huperzine A appears to be a safe memory supplement. Clinical research has shown that Huperzine A is superior to other cholinesterase inhibitors, is rapidly absorbed when taken orally, and possesses a very slow rate of dissociation from the enzyme and a longer duration of action.
Huperzine A has been shown to be effective in inhibiting the actions of AChE to increase acetylcholine concentrations and alleviate some of the symptoms associated with acetylcholine deficiencies. Significant effects have been noted in patients both in terms of their life quality and their ability to retrieve past memories.
1. Watkins PB, Zimmerman HJ, Knapp MJ. Hepatotoxic effects of tacrine
administration in patients with Alzheimer’s disease. JAMA 1994 Apr 6; 271:992-8
2. Raves ML, Harel M, Pang YP, Silman I, Kozikowski AP, Sussman JL. Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A. Nat Struct Biol 1997 Jan;4(1):57-63.
3. Xu SS; Gao ZX; Weng Z; Du ZM; Xu WA; Yang JS; Zhang ML; Tong ZH; Fang YS;Chai XS; et al, Efficacy of tablet huperzine-A on memory’ cognition’ and behavior in Alzheimer`s disease. Chung Kuo Yao Li, Hsueh Pao16:391-5, 1995.
4. (Qian BC, Wang M, Zhou ZF, Chen K, Zhou RR, Chen GS. Pharmacokinetics of tablet huperzine A in six volunteers. Chung Kuo Yao Li Hsueh Pao 1995 Sep;16(5):396-8)
5. Mazurek, A. An open label trial of Huperzine A in the treatment of Alzheimer’s disease. Alternative Therapies, March 1999. Vol. 5, No. 2:97.
6. Saxena A, Qian N, Kovach IM, Kozikowski AP, Pang YP, Vellom DC, Radic Z, Quinn D, Taylor P, Doctor BP. Identification of amino acid residues involved in the binding of Huperzine A to cholinesterases. Protein Sci 1994 Oct;3(10):1770-8.
My Brain Cell Support Plus Formula contains HUPERZINE A with all it’s benefits, as well as 7 other brain enhancing ingredients that work together synergystically to give you a major brain buzz. Click here for more info and to purchase.
Then add in — Brain GO!
For instant brain energy, check out Brain GO! We’re just launching it now, and to celebrate, through the month of June, and possibly July, my partners and I are offering a special 33% discount to you, my followers, using the code word, DRHC33 on checkout. Click Here.
My distributor, Jim, from Tango Advanced Nutrition has these great products on sale this month,
and he is extending the offer to my readers with the discount code above. These sales are rare, so I’d recommend that you load up. Click here.
The Alzheimer’s Summit starts on July 25th. Great speakers, with the latest information, about a condition that we’d thought was hopeless to prevent and treat. There is much that can be done, verified by peer reviewed research. Make sure you listen to Dr Dale Bredesen’s session.
Hyla Cass MD
Marina Del Rey CA 90292
To Subscribe to my newsletter, and get a free copy of my ebook, Reclaim Your Brain, click here